Endocrine Abstracts

Background and aims: Obesity can be cause because of reduction in energy expenditure and /or increased caloric intake. Total calorie intake has increased in recent decades and studies on eating behavior have reported increased intake of foods rich in fats and sugars. Many regulatory pathways for food intake, including those that use serotonin as a neurotransmitter, are affected by obesity or by hypercaloric diets. Summarizing the data known so far, it can be said that reduced ...

Background and AIMS: Obesity can be caused because of reduction in energy expenditure and /or increased caloric intake. Total calorie intake has increased in recent decades, and research and studies on eating behaviour have reported increased intake of foods rich in fats and sugars. Excess calories alone increase body weight and reduce insulin sensitivity, even in healthy individuals who are not obese. In addition, increased consumption of sugars and fats is associated with we...

Background and aims: Although 95% of serotonin is produced in the periphery, its functions have been ignored until now. Recently it became clear that theserotonin system in the periphery regulates multiple physiological aspects independently of the brain-derived serotonin. In particular, peripheral serotonin playsa pivotal function in the regulation of glucose and lipid homeostasis by acting on different organs and cell types. Serotonin produced in pancreatic b- cellspromotes ...

Background and aims95% of serotonin is produced in the periphery. Serotonin system in the periphery regulates multiple physiological aspects. In previous researches that we made, using the Tph1 inhibitor - LP533401 (peripheral serotonin inhibitor) it shows that this agent could be use for treatment of obesity and obesity-induced diabetes in male Wistar rats. With current study we aimed to look more detailed in to fine mechanisms of action of serotonin re...